Madhur Sachan, PhD

My research focuses on understanding microRNAs’ role in the pathophysiology of critical limb ischemia, an atherosclerotic arterial occlusive disease resulting in diminished blood flow to the lower extremities. I obtained my PhD in 2021 at the Center for Life in Extreme Environments, Portland State University, under the mentorship of Dr. Rahul Raghavan. There I investigated the functions of host miRNAs during infection with Coxiella burnetii, a category B select agent and etiological agent for Q fever and chronic endocarditis. This study revealed that miRNAs are an integral component of macrophages’ stage-specific response to C. burnetii infection, and inhibition of miR-143-3p facilitates the pathogen’s intracellular growth. I also examined how different isolates of C. burnetii impact host inflammatory responses and, using single-cell analysis, discovered that specific subpopulations of infected macrophages are seemingly more pathogen friendly than others.
My primary research interest lies at the intersections of non-coding RNAs, immunology, cardiovascular diseases, and drug discovery. In addition, I was also privileged to work with a few international organizations associated with biomedical R&D and healthcare advocacy. My hobbies include hiking, literature, and public speaking.

Keywords

• Non-coding RNAs
• Endothelium and Macrophages
• Omics
• Regulated Cell Death
• Hind Limb Ischemia