The Alan Lerner Symposium showcases the breadth and depth of our research enterprise and facilitates our gathering new ideas to pursue for both bench and bedside research. Thank you again for your unwavering support of our young investigators.
Charlotte Andersson, MD, PhD
Member of the Faculty of Medicine
Brigham and Women’s Hospital
Cardiomyopathy in First-Degree Relatives of Patients Presenting With Acute Myocarditis: Prevalence and Prognostic Significance
Daniel M. Huck, MD, MPH
Instructor in Medicine
Brigham and Women’s Hospital
Adverse Cardiovascular Events Among Younger and Older Patients Referred for Coronary CTAs: The Mass General Brigham CCTA Registry
Victor Nauffal, MD, MSc
Clinical Fellow in Medicine
Brigham and Women’s Hospital
Fibrotic Crossroads: Unveiling Organ-specific and Shared Pathways in the Tapestry of Multi-Organ Fibrosis
FIRST PLACE
Constance Delwarde, PhD
Research Fellow in Medicine
Brigham and Women’s Hospital
ADP-Ribosylation in a Mouse Model of Atherosclerosis: A Potential Novel Link Between Dyslipidemia and Inflammation in Cardiovascular Disease
Mentor: Masanori Aikawa, MD
SECOND PLACE
Erik H. Andrews, MD, MPH
Clinical Fellow in Medicine
Brigham and Women’s Hospital
T-Wave Abnormalities Predict Mortality in Newly Diagnosed Systemic Light Chain Amyloidosis
Mentors: Usha Tedrow, MD and Sharmila Dorbala, MD
THIRD PLACE
Aspasia Tzani, MD, PhD
Research Fellow in Medicine
Brigham and Women’s Hospital
FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis
Mentor: Jorge Plutzky, MD
David Berg, MD, MPH
Assistant Professor of Medicine
Brigham and Women’s Hospital
Assessment of Atherothrombotic Risk in Patients with Type 2 Diabetes Mellitus
Alexander J. Blood, MD
Instructor in Medicine
Brigham and Women’s Hospital
Diabetes Remote Intervention to improVe Use of Evidence-Based Medications Study: A Randomized Evaluation of a Team-Based Remote Education and Medication Management Program to Reduce CV and Kidney Risk.
Vivian Lee, PhD
Instructor in Medicine
Brigham and Women’s Hospital
Variant-to-Function of Coronary Artery Disease: Identifying Novel Regulation of the Notch Pathway in Endothelial Cells
FIRST PLACE
Shruti Rawal, PhD
Research Associate in Medicine
Brigham and Women’s Hospital
Regulation of Succinate Signaling and Immunometabolism in Diabetes-associated Atherosclerosis by miR-369-3p
Mentor: Mark W. Feinberg, MD
SECOND PLACE
Three ways tie!
Rachel Cahalane, PhD
Research Fellow in Medicine
Brigham and Women’s Hospital
Searching for the Mechanisms of Accelerated Calcification in Bioprosthetic Heart Valves
Mentor: Elena Aikawa, MD, PhD
Sarvesh Chelvanambi, PhD
Research Fellow in Medicine
Brigham and Women’s Hospital
HIV-Nef Extracellular Vesicles Modulate Macrophage Heterogeneity to Promote Atherosclerosis
Mentor: Masanori Aikawa, MD
Shi Fang, PhD
Research Fellow in Medicine
Brigham and Women’s Hospital
Functional Characterization of a CCM2 Mutation Associated with Coronary Artery Disease
Mentor: Rajat Gupta, MD
THIRD PLACE
Maria A. Pabon, MD
Clinical Fellow in Medicine
Brigham and Women’s Hospital
Influence of Background Medical Therapy on Efficacy and Safety of Dapagliflozin in Patients With Heart Failure With Improved Ejection Fraction in the DELIVER Trial
Mentor: Scott D. Solomon, MD
Jonathan W. Cunningham, MD, MPH
Instructor in Medicine
Brigham and Women’s Hospital
Aptamer Proteomics for Biomarker Discovery in Heart Failure with Reduced Ejection Fraction
Laurel Y. Lee, MD, DPHIL
Instructor in Medicine
Brigham and Women’s Hospital
T-cell-mediated Endothelial Metabolic Reprogramming in Coronary Artery Disease
Brittany Weber, MD, PhD
Instructor in Medicine
Brigham and Women’s Hospital
Association Between Reduction in Inflammation and Change in Cardiovascular Risk: Results From the LiiRA Study.
Yuri Kim, MD, PhD
Instructor in Medicine
Brigham and Women’s Hospital
Intron-Mediated Enhancer of TTN, Encoding Titin, Regulates Sarcomere Formation and Function
Nicholas Marston, MD
Instructor in Medicine
Brigham and Women’s Hospital
Predictive Power and Value of a CAD Polygenic Risk Score in Primary Prevention Based on Age and Clinical Risk
Andriy Samokhin, PhD
Instructor in Medicine
Brigham and Women’s Hospital
NEDD9 Is a Novel Anti-Fibrotic Therapeutic Target and Biomarker in Pulmonary Arterial Hypertension
FIRST PLACE
Jingshu Chen, PhD
Research Fellow in Medicine
Brigham and Women’s Hospital
Isolation and Primary Culture of Murine Aortic Cells for Atherosclerosis Research
Mentor: Mark W. Feinberg, MD
SECOND PLACE
Rulin Zhuang, PhD
Research Fellow in Medicine
Brigham and Women’s Hospital
KLF10 Deficiency in CD4+ T Cells Exacerbate Angiotensin II-Induced Perivascular Fibrosis
Mentor: Mark W. Feinberg, MD
THIRD PLACE
Wandi Zhu, PhD
Research Fellow in Medicine
Brigham and Women’s Hospital
Piezo1 Mediates a Novel Mechano-Thrombotic Pathway in Cardiometabolic Disease
Mentor: Calum A. MacRae, MD, PhD
Olga Demler, PhD
Assistant Professor of Medicine
Brigham and Women’s Hospital
Heterogeneous Effects of Omega-3 (n-3) Downstream Fatty Acids (FAs) and Oxylipins on Risk of Cardiovascular Disease: Results of Two Metabolomics Substudies of the Randomized Vitamin D and Omega-3 Trial (VITAL)
Shashi Kant, PhD
Assistant Professor of Medicine
Brigham and Women’s Hospital
Neural JNK3 Regulates Blood Flow Recovery After Hindlimb Ischemia in Mice via an Egr1/Creb1 Axis
Muthiah Vaduganathan, MD, MPH
Instructor in Medicine
Brigham and Women’s Hospital
Empagliflozin Delays Progression to Insulin Initiation or Intensification in Patients with Type 2 Diabetes and Cardiovascular Disease: Findings from the EMPA-REG OUTCOME Trial
FIRST PLACE
Tianxiao Liu,PhD
Research Fellow in Medicine
Brigham and Women’s Hospital
Eosinophils Improve Cardiac Functions After Myocardial Infarction
SECOND PLACE
Xin Liu,PhD
Research Fellow in Medicine
Brigham and Women’s Hospital
Eosinophils Protect Mice From Angiotensin-II Perfusion-Induced Abdominal Aortic Aneurysm
THIRD PLACE
Xian Zhang, PhD
Research Fellow in Medicine
Brigham and Women’s Hospital
Divergent Roles of Two IL18 Receptors in Brown Adipose Tissue Thermogenesis and White Adipose Tissue Glucose Metabolism and Insulin Sensitivity
Rajat Gupta, MD
Assistant Professor of Medicine
Brigham and Women’s Hospital
Single Cell Analysis of the Normal Mouse Aorta Reveals Functionally Distinct Endothelial Cell Populations.
Arvind Pandey, MD
Instructor in Medicine
Beth Israel Deaconess Medical Center
CD70 is Essential for Protein Expression in Endothelial Nitric Oxide Synthase.
Sasha Singh, PhD
Instructor in Medicine
Brigham and Women’s Hospital
Insights into Protein Metabolism Heterogeneity Challenge the Reverse Cholesterol Transport Theory: A Novel Mass Spectrometry Platform for Metabolic Tracer Studies in the Clinic
FIRST PLACE
Sio (Henry) Cheng, PhD
Research Fellow in Medicine
Brigham and Women’s Hospital
Identification of MicroRNAs in Human and Mouse Diabetic Critical Limb Ischemia.
SECOND PLACE
Patricia Borck, PhD
Research Fellow in Medicine
Brigham and Women’s Hospital
Inhibition of BRD4 Prevents the Misexpression of Mesenchymal and Fibrotic Markers during Endothelial to Mesenchymal Transition.
THIRD PLACE
Livia Passos, PhD
Research Fellow in Medicine
Brigham and Women’s Hospital
Proteins Associated With Sex Hormone Receptor Activity Contribute to Heart Valve Disease.