Mentor: Dr. Masanori Aikawa
I completed my Masters in Biochemistry from Jiwaji University, Gwalior, India in 2012. I obtained PhD in Life Sciences from Defense Institute of Physiology and Allied sciences, DRDO, Delhi, India in 2019. The study was designed to understand the global transcriptome signatures responsible for high altitude induced thrombosis in humans. The study revealed that hypoxic environment at high altitude induce alterations in the expression of genes involved in haemostasis and blood coagulation pathway, which in turn causes platelet activation and thereby lead to increased susceptibility to venous thrombosis. The study presented the first long noncoding RNA profile of deep vein thrombosis patients at extreme altitude facing the harsh environmental conditions coupled with hypoxia. The part of this work was presented in BCVS, 2019 and got awarded with American Heart Association-Paul Dudley White International scholar award.
After completing my PhD studies, I moved to the United States to pursue postdoctoral studies with Dr. Masanori Aikawa, MD, PhD at Center for Excellence in Vascular Biology, Brigham and Women’s Hospital, Harvard Medical School in January 2020. My postdoctoral study focuses on Systems-based target discovery for accelerated atherosclerosis in chronic kidney disease.
Keywords
- Cardiovascular Diseases
- Systems Biology
- RNA biology
- non-coding RNAs
- Gene Regulation