Mentor: Dr. Masanori Aikawa
Dr. Constance Delwarde is a Research Fellow at Center for Interdisciplinary Cardiovascular Sciences in the Cardiovascular Division of Brigham and Women’s Hospital and Harvard Medical School. While completing her master’s in biology, Biotechnologies and Therapeutic Research from Nantes Université, France, in 2019, she undertook research projects at l’Institut du Thorax in Nantes (France). She completed her PhD in Physiology, Pathophysiology and Medical Systemic Biology in 2022, which has been awarded with the prize of 2022 best fundamental research thesis from the French Society of Cardiology.
During her thesis on Mitral Valve Prolapse, she used multimodality imaging, transcriptomics, epigenetics, molecular biology, and cellular approaches, to establish the involvement of immune cell, and especially macrophages, in the pathophysiology of non-syndromic mitral valve prolapse in the first rat model exhibiting the disease. During her PhD, she received a Mitacs Globalink Grant which allowed her to work 3 months at the Montreal Heart Institute, where she discovered North American lab culture and organization. She then decided to come back to North America as postdoctoral research fellow, to work under the mentorship of Dr. Masanori Aikawa, with high interest on macrophage heterogeneity and cardiovascular diseases. Currently, her work primarily focuses on identifying mechanisms underlying the higher incidence of cardiovascular event in HIV-treated ageing patients.
- Cardiovascular pathophysiology
- Systems Biology
- In vivo pathophysiology
- Macrophage heterogeneity
- Molecular Biology